Joni Kristin Doherty, MD, PHD

Joni Kristin Doherty, M.D., Ph.D., F.A.C.S.


Joni Kristin Doherty, M.D., Ph.D., F.A.C.S.

Personal Information

Joni Kristin Doherty, M.D., Ph.D., F.A.C.S.

1701 E Cesar Chavez Ave Suite 560
Los Angeles, CA 90033-2425
Phone (323) 226-0022

 

Biography

Joni Kristin Doherty, M.D. is AAO-HNS Board Specialty Certified in Neurotology and a Diplomate of the American Board of Otolaryngology—Head & Neck Surgery. Dr. Doherty was a clinical fellow and visiting scientist for the Section on Signal Transduction, Department of Cell & Molecular Biology at the House Clinic and House Ear Institute, Los Angeles, California.

Dr. Doherty was the resident physician at University of Southern California, LAC+USC Medical Center, Department of Otolaryngology—Head & Neck Surgery. Her general surgery internship was at LAC+USC Medical Center, Department of Surgery.


  • Education and Training

    June 4, 2008: AAO-HNS Board Specialty Certification in Neurotology

    2004-2006: House Clinic and House Ear Institute, Los Angeles, California, Clinical – Fellow and Visiting Scientist for the Section on Signal Transduction, Department of Cell & Molecular Biology

    June 1, 2005: Diplomate of the American Board of Otolaryngology—Head & Neck Surgery

    2000-2004: University of Southern California, LAC+USC Medical Center, Department of Otolaryngology—Head & Neck Surgery; Resident Physician

    2002-2003: House Ear Institute, Los Angeles, California

    Department of Histopathology; Visiting Scientist

    1999-2000: LAC+USC Medical Center, Department of Surgery

    General Surgery Internship

    1992-1999: Oregon Health Sciences University School of Medicine M.D., June 9, 1999 Ph.D., June 9, 1999; Department of Cell and Developmental Biology

    1986-1991: University of California, Los Angeles – B.S., Cum Laude, December 1991

  • Employment

    Jan. 2010: Associate Physician & Surgeon: Shohet Ear Associates Medical Group, 770 East Pacific Coast Highway, Seal Beach, CA 90740

    March 2011: Orange County Fall Prevention and Balance Center at Providence,

    Medical Director

    Oct. 2010–13: House Research Institute, Senior Adjunct Scientist, Translational Research Section, Center for Neural Tumor Research

    Aug. 2011-13 Co-Director, Eccles Temporal Bone Histopathology Laboratory, House Research Institute

    2009-2013: Rady Children’s Hospital of San Diego, Department of Otolaryngology,

    Medical Attending Staff

    2006-2010: University of California, San Diego; Department of Surgery, Division of Otolaryngology—Head & Neck Surgery: Assistant Professor and

    Director, Neurotology Fellowship Program

    2006-2009: San Diego Veteran’s Administration Medical Center, Otolaryngology – Attending Staff.

    2004-2006: Clinical Fellow, House Ear Institute, Los Angeles, California

    • Resident Physician, LAC+USC Medical Center, Dept. of Otolaryngology – Head & Neck Surgery, Los Angeles, California
    • Graduate Research Assistant, Department of Biochemistry and Molecular Biology, Clinton Laboratory, Portland, Oregon
    • Research Assistant at Oregon Health Sciences University, Alzheimer’s Disease Foundation, Portland, Oregon
    • Teaching Assistant, Department of Biochemistry, Oregon Health Sciences University, Portland, Oregon
  • Honors and Awards

    April, 2012: Department of Defense Neurofibromatosis Research Program Award (1100095) for “A Single Arm, Monocenter Phase II trial of RAD001 for Treatment of Neurofibromatosis Type 2 Vestibular Schwannoma”, Co-Investigator

    Oct. 2009: New Technology Innovations Award for “HER2 binding Antagonists”, Oregon Health Sciences University, Portland, OR

    July 2007: K08 Career Development Award approval from NIH/NIDCD for ErbB Receptor Regulation of Vestibular Schwannoma Tumorigenesis, funding July 1, 2007 through June 30, 2012.

    March 2007: University of California, San Diego Academic Senate Award for Travel to Scholarly Meeting (Association for Research in Otolaryngology)

    July 2006: American Otologic Society Clinician Scientist Award for “ErbB Regulation of Vestibular Schwannoma Tumorigenesis”

    July 2005: 2005 Rose Taub Award for NOHR project: HER2 Regulation of Human Vestibular Schwannomas

    2005-2006: National Organization for Hearing Research (NOHR) Foundation; Clinical Fellow Award, House Ear Institute, Dept. of Cell and Molecular Biology, “HER2 Regulation of Human Vestibular Schwannomas.”

    2002-2003: NOHR Foundation; New Project Research Award for “Histopathology of the spiral ligament in cochlear otosclerosis: Its role in ion transport and pathogenesis of sensorineural hearing loss”

    1994-1999: Department of Defense USAMMRC Breast Cancer for “Regulation of HER-2/neu oncogene expression and its role in carcinogenesis”

    June 1993: Tartar Trust Fellowship Award for “HER-2/neu expression in Ovarian Cancer”, Oregon Health Sciences University, Dept. of Biochemistry and Molecular Biology

  • Publications

    Manuscripts

    Richard C, Doherty JK, Fayad JN, Cordero A, Linthicum FH Jr. Identification of target proteins involved in cochlear otosclerosis. Otol Neurotol 2015;36(5):923-31. PMID 25569361

    Doherty J, Go JL, Linthicum FH Jr. Neurofibromatosis 2 invasion of the internal auditory canal wall: Clinical Significance. Otol Neurotol 2014:35(9);1662-8. NIHMS597780

    Toren A, Reichardt JK, Andalibi A Hsu NY, Doherty J, Slattery W, Mehrian-Shaw R. Novel age-dependent targets in vestibular schwannoma. Hum Genomics 2014:8;10 PMID 24980480

    Linthicum FH Jr, Doherty J, Webster P, Makarem A. The periductal channels of the endolymphatic duct, hydrodynamic implications. Otolaryngol Head Neck Surg 2014 Mar;150(3):441-7. PMID: 24376120

    Linthicum FH Jr, Doherty J, Berliner KI. Idiopathic sudden sensorineural hearing loss: Vascular or Viral? Otolaryngol Head Neck Surg 2013; 149(6):914-7. PMID 24067949

    Cassis A, Doherty JK, Daspit CP, Linthicum FH Jr. Short-term histopathology effects of gamma knife radiosurgery on a vestibular schwannoma. Otolaryngol Head Neck Surg 2013;148(6):1056-8. PMID 23426712

    Kimmel RA, Doherty J, Slattery WH III, Linthicum FH Jr. Recurrent schwannoma post-irradiation: Histological review reveals mixed schwannoma and meningioma. Otolaryngol Head Neck Surg 2013;148(5):886-8 PMID 23380761.

    Treadway JP, Doherty JK, Linthicum FH Jr. Modiolar dehiscence associated with sensorineural hearing loss. Otol Neurotol 2013 Jan;34(1):e4-5 PMID: 23235552

    Doherty JK, Linthicum FH Jr. Adipose replacing intracochlear architecture after meningioma removal. Otol Neurotol 2013;34(2):e8-9. PMID: 22972425

    Richard C, Linthicum FH Jr, Doherty JK. Incidental discovery of a temporal bone chondroblastoma on an archived histopathologic section. Otol Neurotol 2013;34(5):e38-9 PMID: 23187929

    Yi D, Kuo SZ, Zheng H, Abhold EL, Brown CM, Doherty JK, Wang-Rodriguez J, Harris JP, Ongkeko WM. Activation of PDGFR and EGFR Promotes the Acquisition of a Stem Cell-like Phenotype in Schwannomas. Otol Neurotol 2012;33(9):1640-7. PMID: 22935817

    Richard C, Doherty JK, Treadway JP, Fayad JN, Linthicum FH. Multiple otosclerotic foci: Impact on cochlear function. Otolaryngol Head Neck Surg 2012;147(2 supp):214-15. PMID 25718762

    Richard C, Fayad JN, Doherty JK, Linthicum FH, Jr. Cochlear implant round window versus cochleostomy insertion techniques: Histological findings. Otol Neurotol 2012;33(7):1181-7. PMID: 22892806

    Baik FM, Nguyen L, Doherty JK, Harris JP, Mafee MF, Nguyen QT. Comparative case series of exostoses and osteomas of the internal auditory canal. Ann Otol Rhinol Laryngol 2011;120:255-60. PMID: 21585156

    Ahmad Z, Brown CR, Ryan AF, Doherty JK. ErbB expression, activation, and inhibition with lapatinib and tyrophostin (AG825) in human vestibular schwannomas. Manuscript in press for Otol Neurotol 2011;32:841-7. PMID: 21659924

    Blair KJ, Kiang A, Wang-Rodriguez J, Yu MA, Doherty JK, Ongkeko WM. EGF and bFGF promote invasion that is modulated by PI3/Akt kinase and Erk in vestibular schwannoma. Otol Neurotol 2011;32(2):308-14. PMID: 21178801

    Altuna X, Lopez J, Yu A, Arandazi MJ, Harris JP, Wang-Rodriguez J, An Y, Dobrow R, Doherty JK, Onkeko WR. Potential Role of Imatinib Mesylate (Gleevec, STI-571) in the Treatment of Vestibular Schwannoma. Otol Neurotol 2011;32(1):163-70. PMID: 2115729

    Brown C, Ahmad Z, Ryan A, Doherty JK. Estrogen receptor expression in human vestibular schwannoma. Otol Neurotol 2011;32(1):158-62. PMID: 21099731

    Nguyen LT, Baik FM, Doherty JK, Harris JP, Nguyen QT. Exostoses and osteomas of the internal auditory canals. Laryngoscope 2010;120 Suppl 4:S215. PMID: 21225813

    Patel AK, Barkdul G, Doherty JK. Cochlear implantation in chronic suppurative otitis media. Operative Techniques in Otolaryngol 2010.

    Teufert KB, Doherty J. Endolymphatic sac shunt, labyrinthectomy, and vestibular nerve section in Meniere’s disease. Otolaryngol Clin North Am 2010; 43(5):1091-1111. PMID: 20713247

    Ahmad Z, Brown C, Patel AK, Ryan AF, Ongkeko RW, Doherty JK. Merlin knockdown in human Schwann cells: clues to vestibular schwanoma tumorigenesis. Otol Neurotol 2010;31(3):460-6. PMID: 20195187

    King J, Kinney A, Iacobellis S, Alexander TH, Harris JP, Torre P 3rd, Doherty JK, Nguyen, QT,. Laterality of exostosis in surfers due to evaporative cooling effect. Otol Neurotol 2010;31(2):345-51. PMID: 19806064

    Fisher LM, Doherty JK, Lev MH, Slattery WH III. Concordance between right and left vestibular schwannoma growth rates and hearing changes in NF2. Otol Neurotol 2009;30(6):835-41. PMID: 19704365

    Ryan AF, Mullen LM, Doherty JK. Cellular targeting for cochlear gene therapy. Adv Otorhinolaryngol 2009;66:99-115. PMID: 19494575

    Patel A, Alexander TH, Andalibi A, Ryan AF, Doherty JK. Vestibular schwannoma quantitative PCR expression of estrogen and progesterone receptors. Laryngoscope 2008;118:1458-63. PMID: 18670322

    Doherty JK, Ongkeko W, Crawley B, Andalibi A, Ryan AF. ErbB and Nrg: Potential molecular targets for vestibular schwannoma pharmacotherapy. Otol Neurotol 2008;29(1):50-57. PMID: 18199957

    Fisher LM, Doherty JK, Lev MH, Slattery WH 3rd. Distribution of nonvestibular cranial nerve schwannomas in Neurofibromatosis 2. Otol Neurotol 2007;28(8):1083-90. PMID: 18043434

    Brackmann DE, Doherty JK. Idiopathic intracranial hypertension associated with an enlarged fallopian canal and unilateral facial palsy. Otol Neurotol 2007; 28(5):715-8. PMID: 17667777

    Doherty JK, Yong M, Maceri D. Endolymphatic sac tumor: Report of three cases and discussion of management. ENT Journal 2007;86:30-5. PMID: 17315832

    Doherty JK, Brackmann DE. Malignant melanoma of the CPA: Diagnosis and Management. Otol Neurotol 2007;28:529-37. PMID: 17414177

    Doherty JK, Friedman RA. Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngology—Head & Neck Surgery 2006;14(5):305-13. PMID: 16974142

    House JW, Doherty JK, Fisher L, Masuda A, Derebery MJ. Meniere’s disease: prevalence of contralateral ear involvement. Otol Neurotol, 2006 Apr; 27(3):355-61. PMID: 16639274

    Doherty JK and Luxford WM. Management of Cochleostomy in patients with large vestibular aqueduct receiving cochlear implants. Operative Techniques in Otolaryngology, 2005;16:82-5.

    Doherty JK, Maceri DM. Osscicular discontinuity and exostoses in Proteus syndrome: a case report. Ann Otolaryngol - Head Neck Surg 2005;114:242-246. PMID: 15825577

    Doherty JK, Linthicum FH, Jr. Cochlear endosteal erosion with focal osteomyelitis induced by cochlear implantation. Otol Neurotol 2004;25(6):1029-30. PMID: 15547439

    Doherty JK, Linthicum FH, Jr. Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level. Otol Neurotol 2004; 25(4): 457-64. PMID: 15241221

    Doherty JK, Lum C, Doherty C. Pathology Quiz Case 2. Pemphigus Vulgaris (PV). Arch Otolaryngol - Head Neck Surg 2003, 129(2):254, 256-7. PMID: 12578463

    Doherty JK, Slattery, WH, III. Autologous fat grafting for the refractory patulous Eustachian tube. Otolaryngol - Head Neck Surg 2003, 128(1):88-91. PMID: 12574764

    Zim S, Doherty JK, Ma Y, Lee E. Pathology quiz case. Castleman’s disease (CD), unicentric, hyaline vascular type. Arch Otolaryngol Head Neck Surg 2001, 127(9): 1133-5. PMID: 11556867

    Azios, NG, Romero FJ, Denton MC, Doherty JK, Clinton GM. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor. Oncogene 2001, 20(37):5199-5209. PMID: 11526509

    Doherty JK, Bond C, Jardim A, Adelman JP, Clinton GM. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc Natl Acad Sci, USA 96(19): 10869-74, 1999. PMID: 10485918

    Doherty JK, Bond CT, Hua W, Adelman JP, Clinton GM. An alternative HER-2/neu transcript of 8 kb has an extended 3’UTR and displays increased stability in SKOV-3 ovarian carcinoma cells. Gynec Otol 74(3): 408-15, 1999. PMID: 10479501

    Christianson TA, Doherty JK, Lin YJ, Holmes R, Keenan EJ, Clinton GM. A truncated HER-2/neu protein with kinase activity that correlates with shedding and is elevated in metastatic breast cancer. Cancer Research 58(22): 5123-9, 1998. PMID: 9823322

    Textbook Chapters

    Joni K. Doherty. Otolaryngologic Manifestations of Proteus Syndrome. In press.

    Patel AK, Barkdul G, Doherty JK. Cochlear Implantation in Chronic Otitis Media. Operative Techniches in Otolaryngology.

    Teufert K, Doherty JK. Surgical Management of Meniere’s Disease. Otolaryngologic Clinics of North America.

    Ryan AF, Mullen LM, Doherty JK. Cellular Targeting for cochlear gene therapy. Adv Otorhinolaryngol 2009;66:99-115.

    Patel AK, Doherty JK, Davidson TM. External Ear Trauma. In: Textbook of Otolaryngology (in Spanish) Chapter 141.

    Doherty JK, Friedman RA, Lim D. Clinical Molecular Disorders. In: Pensak ML, Hughes GB, editors: Clinical Otology, 3rd Edition.

    Doherty JK, Friedman RA, Ryan AF. Molecular Biology of Hearing and Balance. In: Ballenger’s Otorhinolaryngology.

  • U.S. Patents

    7/31/2000: Doherty JK, Clinton GM, Adelman JP. HER-2 Binding Antagonists. Serial No. 09/630,155 (DIV), legal reference no. 49321-10; issued. International filing: PCT Patent International Application No. PCT/US00/01484, publication no. WO 00/44403, Ref. No. 452,1/20/2000

    9/22/2009: Clinton GM, Doherty JK, Adelman JP. HER-2 Binding Antagonists, Continuation-in-part. Serial No. 10/302,663, legal ref. no. 49321-73.

  • Memberships/Affiliations

    Sept. 2015-8: American Otological Society Planning Committee

    May, 2015-8: American Neurotology Society Education Committee

    April 2015: Fellow of the American Otological Society

    June 2014: Otosclerosis Study Club, member

    Oct. 2013: Hearing Health Foundation Council of Medical Trustees

    Sept. 2013: Orange County Medical Association

    Nov. 2012: Neurosurgery Journal, reviewer

    April 2012: Certified Yoga Instructor, Core Power Yoga

    Feb. 2012: Audiology & Neurotology Journal, Guest Associate Editor to Jeffrey P. Harris

    2011-present: Research Endpoints in Neurofibromatosis and Schwannomatosis (REiNS), member of Committee on Hearing and Functional Outcomes Determination for Clinical Trials

    2011-present Long Beach Memorial Hospital and Miller Children’s Hospital, staff

    2010-present: HearAid Foundation, Board member

    2010-present Hoag Hospital, Dept. of Otolaryngology, staff surgeon

    2010-present: Los Alamitos Medical Center, Dept. of Otolaryngology, staff surgeon

    2010-present American Board of Otolaryngology Task Force member/writer for Board Examination questions

    2010-2012: Impact Cambodia: visiting surgeon and clinical instructor (annual)

    2010-present: Orange County Society of Otolaryngology – Head & Neck Surgery

    2009-present: American College of Surgeons, Fellow

    2009-present: Otology & Neurotology, Editorial Board

    2009-present: AAO-HNS scientific education & communications liason for the Association for Research in Otolaryngology on Implantable Hearing Devices

    2009-present: Rady Children’s Hospital San Diego, Attending staff surgeon

    2009-present Certification Program for Otolarngology Personnel, committee member

    2009-present: Alcon Laboratories, speaker’s bureau

    2009-present: Mayflower Medical Outreach; visiting physician/surgeon in Managua and Jinotega, Nicaragua (annual)

    2008-present: CORE research grant reviewer for the Academy of Otolaryngology – Head and Neck Surgery (AAO-HNS)

    2008-present: Otolaryngology – Head & Neck Surgery, journal reviewer

    2007-2009: American College of Surgeons, Associate Fellow

    2007-present: Annals of Otolaryngology, journal reviewer

    2006-2010: San Diego Medical Society, member

    2006-present: California Medical Association

    2006-present:  Association for Research in Otolaryngology, member

    2006-present: Triological Society, candidate member

    2006-present: Expert Opinion on Therapeutic Patents, referee (Informa Healthcare, London, UK)

    2006-present: American Neurotology Society, member

    2005-present: American Academy of Otolaryngology—Head & Neck member and diplomate

    2005-present: Global ENT Outreach, annual missionary physician/surgeon/professor

    2004-present: Otology & Neurotology, journal reviewer

    2004-present: California Medical Society, member

    1988-present: PADI, open water diver